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| In the monolayer assay the anti-proliferative and cytotoxic activity of test compounds is determined in permanent tumor cell lines. It is mainly used as a rapid initial screen to select the most promising compounds based on potency and selectivity. | This includes drug combination studies with Combination Index (CI) determination according to Chou-Talalay. ONCOTEST has established more than 40 unique cell lines directly from patient-derived tumor xenografts. |
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