Compound testing at ONCOTEST can follow two general time and money saving approaches :
| Target oriented approach: If the targets of your compounds are known and/or only a few compounds have to be tested specifically, we suggest to first analyse the target expression of our tumors in order to select the most suitable models for further testing. Once tumors have been selected from results from the Affimetrix chips or microarray data, we directly test your compounds in our clonogenic assay and later in in vivo studies. Drug oriented approach: If many compounds (>20) are to be tested, we favor the monolayer assay to first select the most potent and tumor specific compounds. In a following step, selected compounds will be tested in our clonogenic assay and in in vivo studies. Packages of each approach can be combined individually upon your request. |
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